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  • Title: A quinoline-based fluorometric and colorimetric dual-modal pH probe and its application in bioimaging.
    Author: Zhu Q, Li Z, Mu L, Zeng X, Redshaw C, Wei G.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2018 Jan 05; 188():230-236. PubMed ID: 28715691.
    Abstract:
    The compound (E)-8-hydroxyl-2-[(E)-2-(2, 4-dihydroxyphenyl)vinyl]-quinoline (1) has been developed as a fluorometric and colorimetric dual-modal probe for pH detection in solution and in vivo. Remarkable changes in the fluorescence intensity with large Stokes shifts and colorimetric responses were observed as a function of pH. The sensing mechanisms involving protonation and deprotonation processes over the acidic and alkaline pH ranges were confirmed by 1H NMR and IR spectroscopic analysis. Furthermore, the application of probe 1 for the imaging of live PC3 cells was successfully achieved. Test strips based on probe 1 were fabricated, and were found to act as a convenient and efficient pH test kits.
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