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  • Title: Depression of plasma luteinizing hormone concentration in quail by the anticholinesterase insecticide parathion.
    Author: Rattner BA, Clarke RN, Ottinger MA.
    Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1986; 83(2):451-3. PubMed ID: 2872014.
    Abstract:
    To examine the effects of parathion on basal plasma luteinizing hormone (LH) concentration, male Japanese quail (Coturnix japonica) were orally intubated with 0, 5 or 10 mg/kg parathion and sacrificed after 4, 8 and 24 hr. At the 5 mg/kg dose, plasma LH levels were reduced at 4 and 8 hr, but returned to control values by 24 hr. Brain acetylcholinesterase activity was substantially reduced by 10 mg/kg parathion (52, 75 and 37% inhibition at 4, 8 and 24 hr, respectively) and plasma LH concentration remained depressed through the 24-hr period. These findings suggest that the organophosphorus insecticide parathion may alter plasma LH concentration in a manner which might impair reproductive activity, and provide indirect evidence for a cholinergic component in the regulation of LH secretion in quail.
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