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  • Title: Tissue atenolol levels following chronic beta-adrenoceptor blockade using oral atenolol in dogs.
    Author: Davies MK, McAinsh J.
    Journal: J Pharm Pharmacol; 1986 Apr; 38(4):316-9. PubMed ID: 2872302.
    Abstract:
    Tissue atenolol concentrations are high following chronic continuous beta-adrenoceptor blockade in dogs. Furthermore, significant concentrations of this poorly lipid soluble drug are found within the central nervous system after chronic dosing. It is suggested that all beta-adrenoceptor blocking agents may enter the central nervous system in significant and sufficient quantities to account for a central antihypertensive action of this group of compounds. Sequestration of beta-adrenoceptor agents in the CNS or other tissues may account for other clinically observed effects including adaptive effects.
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