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  • Title: In-vitro release of [14C]glutamate from dentate gyrus is modulated by GABA.
    Author: Spencer P, Lynch MA, Bliss TV.
    Journal: J Pharm Pharmacol; 1986 May; 38(5):393-5. PubMed ID: 2872320.
    Abstract:
    The effect of GABA (10(-3) and 10(-4) M) on the release of preloaded [14C]glutamate from slices of rat dentate gyrus, in response to K+ stimulation, was studied in Ca2+-free and normal Krebs solutions. Release in Ca2+-free solution was significantly enhanced, but there was no change in release in normal Krebs solution. These results imply that Ca2+-dependent (presumably neuronal) release of glutamate from the dentate gyrus is depressed by GABA, while non-neuronal Ca2+-independent release is enhanced.
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