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  • Title: Bulbocapnine is not a selective DA1 receptor antagonist.
    Author: Kohli JD, Glock D, Goldberg LI.
    Journal: J Pharm Pharmacol; 1986 May; 38(5):401-2. PubMed ID: 2872323.
    Abstract:
    Antagonist activity of bulbocapnine on DA1 versus DA2 dopamine receptors was studied simultaneously in a dog under pentobarbitone anaesthesia and without phenoxybenzamine pretreatment. Fenoldopam (SK&F 82526) injected into the renal artery was the DA1 agonist and dipropyl dopamine or piribedil injected into the femoral artery were the DA2 agonists. Both at 0.5 and 1 mg kg-1 doses intravenous bulbocapnine caused nearly equal inhibition of DA1 and DA2 dopamine receptor-mediated responses. Our results show that under these experimental conditions bulbocapnine is not a selective DA1 dopamine antagonist.
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