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  • Title: [Effect of beta-adrenergic blockaders and their combination with an alpha-adrenergic blockader on physical exertion tolerance in patients with hypertension].
    Author: Smirnov GB.
    Journal: Kardiologiia; 1986 Mar; 26(3):33-6. PubMed ID: 2872358.
    Abstract:
    The effect of long-term treatment with propranolol (45 patients), trasicor (15), visken (23) and combinations thereof with phentolamine and labetalol (12) on submaximum exercise tolerance was studied in patients with second-stage essential hypertension. Beta-adrenoblockers had no effect on total systemic oxygen consumption, but reduced significantly its myocardial consumption and brought down systolic and diastolic arterial blood pressure at rest and during exercise. Differences were demonstrated in the hemodynamic mechanism of the decline in resting arterial pressure: under the effect of propranolol and trasicor, peripheral resistance increased insufficiently in response to a fall of the cardiac index; visken and labetalol depressed peripheral resistance without affecting the cardiac index. During exercise, all 4 beta-adrenoblockers reduced the cardiac index, mainly at the expense of a smaller pulse rate. An additional hypotensive effect of phentolamine that owes to reduced peripheral resistance was demonstrated.
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