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  • Title: Comparative efficacy of estazolam, flurazepam, and placebo in outpatients with insomnia.
    Author: Dominguez RA, Goldstein BJ, Jacobson AF, Steinbook RM.
    Journal: J Clin Psychiatry; 1986 Jul; 47(7):362-5. PubMed ID: 2873132.
    Abstract:
    The efficacy and safety of estazolam, an investigational triazolobenzodiazepine, and flurazepam were compared in 65 insomniac outpatients. Patients completed sleep questionnaires each morning. Global evaluations demonstrated that both treatments were significantly superior to placebo. However, estazolam was preferred over flurazepam in a global rating that reflected how well rested and refreshed the subjects felt on arising. Improvement in complaints of difficulty in going to sleep showed only a trend toward significance favoring estazolam and flurazepam over placebo. Residual daytime drowsiness and fatigue accounted for approximately 70% of all side effects with both active treatments. Significantly more side effects occurred with flurazepam than with estazolam. Flurazepam-treated patients had a significantly more severe rating of adverse reactions than did placebo-treated patients.
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