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  • Title: [Protective effect of adrenergic alpha 2-receptor agonists in hypoxic hypoxia].
    Author: Kulinskiĭ VI, Ol'khovskiĭ IA, Kovalevskiĭ AN.
    Journal: Biull Eksp Biol Med; 1986 Jun; 101(6):669-71. PubMed ID: 2873847.
    Abstract:
    The antihypoxic effect of alpha 2-adrenoceptor agonists was studied by two different approaches: reproduction of the effect by a number of alpha 2-agonists and its blockade with selective antagonists. The data obtained suggest that alpha 2-adrenoceptor agonists increase the survival and the lifespan of mice in all the models of acute hypoxic hypoxia under study. A close correlation between antihypoxic action of alpha 2-adrenoceptor agonists and their anticalorigenic effect was established (r = +0.87; P less than 0.01).
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