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  • Title: Ischemic CA-1 pyramidal cell loss is prevented by preischemic colchicine destruction of dentate gyrus granule cells.
    Author: Johansen FF, Jørgensen MB, Diemer NH.
    Journal: Brain Res; 1986 Jul 09; 377(2):344-7. PubMed ID: 2873869.
    Abstract:
    Hippocampal CA-1 pyramidal cell damage was produced by 20 min of cerebral ischemia. Colchicine destruction of the dentate gyrus granule cells 11 days before ischemia prevented the CA-1 cell loss. It is suggested that the protective effect of degranulation on ischemic CA-1 pyramidal cell damage is due to reduction of glutamate release in CA-1 during and after ischemia.
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