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  • Title: Collision of Lymphoepithelioma-like Carcinoma with Diffuse Large B-cell Lymphoma of the Stomach: A Case Report.
    Author: Liu L, Zhao H, Sheng L, Yang P, Zhou H, Wang R.
    Journal: Anticancer Res; 2017 Aug; 37(8):4569-4573. PubMed ID: 28739754.
    Abstract:
    BACKGROUND/AIM: Collision of Epstein-Barr virus (EBV)-associated lymphoepithelioma-like carcinoma (LELC) with non-Hodgkin's lymphoma of the stomach is extremely rare. PATIENTS AND METHODS: Herein we report a case of LELC with primary diffuse large B-cell lymphoma (DLBCL) of the stomach in a 65-year-old patient. RESULTS: Gastric endoscopy showed a poorly differentiated adenocarcinoma of the stomach. The patient underwent radical gastrectomy, and histopathological examinations revealed the collision of LELC and DLBCL of the stomach. In situ hybridization showed that most carcinoma cells of LELC were positive for EBV-encoded small RNA (EBER) suggesting that the virus infection happened in the early stage of tumorigenesis, while DLBCL was negative. CONCLUSION: This is the first report of collision of EBV-associated LELC with primary DLBCL of the stomach.
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