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  • Title: Near-infrared spectroscopy monitoring and control of the fluidized bed granulation and coating processes-A review.
    Author: Liu R, Li L, Yin W, Xu D, Zang H.
    Journal: Int J Pharm; 2017 Sep 15; 530(1-2):308-315. PubMed ID: 28743552.
    Abstract:
    The fluidized bed granulation and pellets coating technologies are widely used in pharmaceutical industry, because the particles made in a fluidized bed have good flowability, compressibility, and the coating thickness of pellets are homogeneous. With the popularization of process analytical technology (PAT), real-time analysis for critical quality attributes (CQA) was getting more attention. Near-infrared (NIR) spectroscopy, as a PAT tool, could realize the real-time monitoring and control during the granulating and coating processes, which could optimize the manufacturing processes. This article reviewed the application of NIR spectroscopy in CQA (moisture content, particle size and tablet/pellet thickness) monitoring during fluidized bed granulation and coating processes. Through this review, we would like to provide references for realizing automated control and intelligent production in fluidized bed granulation and pellets coating of pharmaceutical industry.
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