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  • Title: Role of NF-κB, PI3K, MAPK/ERK 1/2, and p38 in Erythropoietin Production by Bone Marrow Nuclears under Conditions of Immobilization Stress.
    Author: Miroshnichenko LA, Zhdanov VV, Udut EV, Polyakova TY, Zyuz'kov GN, Simanina EV, Sherstoboev EY, Stavrova LA, Agafonov VI, Minakova MY, Chaikovskii AV, Dygai AM.
    Journal: Bull Exp Biol Med; 2017 Jul; 163(3):352-355. PubMed ID: 28744650.
    Abstract:
    The involvement of the studied signal cascades in the regulation of erythropoietin production by bone marrow nuclears under conditions of immobilization stress depends on the type of the hemopoiesis-inducing microenvironment cells and the period of blood system reaction to stress exposure. Secretory activity of monocytes is regulated mainly by PI3K improving cell resistance to disturbances. The functional role of signal cascades involved in the production of erythropoietin by T cells is determined by the stage of the common adaptation syndrome.
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