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  • Title: Exercise-induced hand tremor: a possible test for beta 2-adrenoceptor selectivity in man?
    Author: Abila B, Wilson JF, Marshall RW, Richens A.
    Journal: Br J Clin Pharmacol; 1986 Jul; 22(1):104-7. PubMed ID: 2874824.
    Abstract:
    The effects of intravenous doses of propranolol, sotalol, timolol, atenolol and placebo on exercise-induced tachycardia and exercise-induced increases in hand tremor were assessed in four healthy volunteers. All active drugs produced significant reductions in exercise-induced tachycardia. Exercise caused consistent significant increases in hand tremor which were blocked by the three non-cardioselective drugs but not by atenolol or placebo. The blockade of exercise-induced hand tremor is suggested as a possible test for the assessment of the selectivity of beta-adrenoceptor blockade in man.
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