These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Evidence against leukotriene-mediation of propranolol-induced airway hyperreactivity to acetylcholine.
    Author: Murlas C.
    Journal: J Pharm Pharmacol; 1986 Jul; 38(7):550-2. PubMed ID: 2875162.
    Abstract:
    In unanaesthetized guinea-pigs, propranolol treatment (0.1 mg kg-1 i.v.) substantially increased reactivity to intravenous acetylcholine infusion or aerosolized histamine to a comparable degree. Neither BW755c (5 mg kg-1 i.v.), FPL 55712 (1 mg kg-1 i.v.), nor piriprost (5 mg kg-1 i.v.) pretreatment influenced propranolol's effect on muscarinic reactivity although BW755c abolished histaminic hyperreactivity. This suggests that propranolol-induced muscarinic hyperreactivity in the guinea-pig is not mediated by leukotrienes whereas histaminic hyperreactivity may be.
    [Abstract] [Full Text] [Related] [New Search]