These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Discovery of novel 4(1H)-quinolone derivatives as potential antiproliferative and apoptosis inducing agents.
    Author: Zhou P, Huang L, Zhou J, Jiang B, Zhao Y, Deng X, Zhao Q, Li F.
    Journal: Bioorg Med Chem Lett; 2017 Sep 01; 27(17):4185-4189. PubMed ID: 28757067.
    Abstract:
    A series of novel 4(1H)-quinolone derivatives was synthesized and evaluated for antiproliferative activity in vitro. The results showed that these compounds exhibited more potent antiproliferative effect against a panel of human tumorcelllines than the lead compound 7-chloro-4(1H)-quinolone 1. Compound 7e was found to be the most potent antiproliferative agent and to exhibit selective cytotoxic activity against HepG2 cell lines with IC50 value lower than 1.0μM. Annexin V/FITC-PI assay showed that compound 7e induced apoptosis in HepG2 cells with a dose-dependent manner. Western blotting analysis indicated that compound 7e induced cell cycle arrest in G2/M phase by p53-depedent pathway.
    [Abstract] [Full Text] [Related] [New Search]