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  • Title: HLA-DQ polymorphism analyzed by sequential restriction endonuclease DNA digestion.
    Author: Trucco M, Rosenshine S, Cascino I, Duquesnoy RJ.
    Journal: Immunogenetics; 1986; 24(3):184-90. PubMed ID: 2875943.
    Abstract:
    A direct, physical correspondence between certain Pst I-generated genomic DNA fragments and Taq I-generated fragments, revealed with HLA-DQ alpha or -DQ beta gene probes, has been demonstrated. As an immediate consequence, the nature of the DQ and DX hybridized genes contained in the fragments was established. Taq I-generated DQ allelic forms which associate with serologically defined DR1, DR2, and DRw6 specificities were also proven to be sensu stricto "splits" of the Pst I-generated allelic form associated with all three DR specificities.
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