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  • Title: T cell independent Thy-1 allo-antibody response with the use of transgenic mice.
    Author: Isobe K, Kollias G, Kolsto AB, Grosveld F.
    Journal: J Immunol; 1986 Oct 01; 137(7):2089-92. PubMed ID: 2876039.
    Abstract:
    We have introduced a mouse Thy-1.1 gene into the germline of Thy-1.2 mice. The introduced gene was shown to be expressed at very high levels in thymocytes when compared with the endogenous gene. Transgenic thymocytes were shown to evoke a higher than normal primary anti-Thy-1.1 antibody response in plaque-forming cell (PFC) assays. This result suggests that a direct quantitative interaction of the Thy-1 antigen activates the B cell response.
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