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  • Title: Deaminative Strategy for the Visible-Light-Mediated Generation of Alkyl Radicals.
    Author: Klauck FJR, James MJ, Glorius F.
    Journal: Angew Chem Int Ed Engl; 2017 Sep 25; 56(40):12336-12339. PubMed ID: 28762257.
    Abstract:
    A deaminative strategy for the visible-light-mediated generation of alkyl radicals from redox-activated primary amine precursors is described. Abundant and inexpensive primary amine feedstocks, including amino acids, were converted in a single step into redox-active pyridinium salts and subsequently into alkyl radicals by reaction with an excited-state photocatalyst. The broad synthetic potential of this protocol was demonstrated by the alkylation of a number of heteroarenes under mild conditions.
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