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  • Title: Ciliary Motility: Regulation of Axonemal Dynein Motors.
    Author: Viswanadha R, Sale WS, Porter ME.
    Journal: Cold Spring Harb Perspect Biol; 2017 Aug 01; 9(8):. PubMed ID: 28765157.
    Abstract:
    Ciliary motility is crucial for the development and health of many organisms. Motility depends on the coordinated activity of multiple dynein motors arranged in a precise pattern on the outer doublet microtubules. Although significant progress has been made in elucidating the composition and organization of the dyneins, a comprehensive understanding of dynein regulation is lacking. Here, we focus on two conserved signaling complexes located at the base of the radial spokes. These include the I1/f inner dynein arm associated with radial spoke 1 and the calmodulin- and spoke-associated complex and the nexin-dynein regulatory complex associated with radial spoke 2. Current research is focused on understanding how these two axonemal hubs coordinate and regulate the dynein motors and ciliary motility.
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