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  • Title: Immunohistochemical evidence for extrinsic and intrinsic opioid systems in the guinea pig superior cervical ganglion.
    Author: Kummer W, Heym C, Colombo M, Lang R.
    Journal: Anat Embryol (Berl); 1986; 174(3):401-5. PubMed ID: 2876660.
    Abstract:
    Immunohistochemical localization of the opioid peptides alpha-neo-endorphin (alpha-neo-END), dynorphin A (DYN) and leu-enkephalin (leu-ENK) in the guinea pig superior cervical ganglion (SCG) was studied following central denervation, peripheral axotomy, and after application of the depleting drug reserpine and of the neurotoxin 6-hydroxydopamine. The paraganglionic cells of the SCG are shown to form an intrinsic opioid--(alpha-neo-END, DYN, leu-ENK)--immunoreactive system being not visibly responsive to the experimental procedures. Leu-ENK-immunoreactive fibres ascend in the preganglionic trunk and supply fibre baskets to defined clusters of postganglionic neurones. Principal ganglion cells of the SCG containing alpha-neo-END- and DYN-immunoreactivity project to extraganglionic targets via the postganglionic nerves. These findings are indicative of a sympathetic alpha-neo-END-ergic and DYN-ergic innervation of effector organs. They also point to a modulatory function of opioids on neuronal activity in a paravertebral ganglion.
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