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  • Title: Neuroleptic-induced catatonia after abrupt withdrawal of amantadine during neuroleptic therapy.
    Author: Brown CS, Wittkowsky AK, Bryant SG.
    Journal: Pharmacotherapy; 1986; 6(4):193-5. PubMed ID: 2877444.
    Abstract:
    Catatonic reactions to high-potency neuroleptic drugs have been described in the literature. Our patient developed neuroleptic-induced catatonia (NIC) after abrupt withdrawal of amantadine, a dopaminergic agent that has been implicated in neuroleptic malignant syndrome (NMS) on its discontinuation. This case report adds support to the hypothesis that NIC and NMS are 2 syndromes on a continuum of dopamine blockade, each of which may be treated with or uncovered by amantadine therapy.
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