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  • Title: [Prevention of ulcer disease].
    Author: Loizeau E.
    Journal: Schweiz Med Wochenschr; 1986 Oct 04; 116(40):1371-4. PubMed ID: 2877491.
    Abstract:
    H2-receptor antagonists, sucralfate, pirenzepine and antacids are effective, when given prophylactically, in preventing relapse of peptic ulcer. H2-receptor antagonists and sucralfate are the most widely used and are virtually free of side effects. Cessation of smoking, a balanced diet and a calm life-style are also part of the prophylaxis. The incidence of relapse is reduced by 50-80% over a period of 1-2 years. The economic and clinical benefits of prophylaxis are shown. It is indicated in cases of chronic, relapsing ulcers; complicated ulcers; in medically compromised subjects and in those with heavy responsibilities. Prophylaxis is unduly costly when given after a first episode of peptic ulcer or when episodes are infrequent. For patients with one or two episodes a year the decision to give prophylaxis depends on the patient's wishes. Prophylaxis of stress-induced haemorrhagic lesions depends on the securing of an intragastric pH greater than 3.5-5, usually achieved by hourly administration of antacids. Methylated prostaglandins and H2-receptor antagonists can prevent drug induced peptic lesions. Under the protection of one of these drugs it is possible to continue antiinflammatory treatment at the lowest possible dose.
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