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  • Title: Beta-globin gene polymorphism in Saudis--triple Hpa I fragments.
    Author: el-Hazmi MA, Jabbar FA, Al-Swailem AR, Warsy AS.
    Journal: Hum Genet; 1986 Nov; 74(3):313-5. PubMed ID: 2877940.
    Abstract:
    In an attempt to investigate beta-globin gene polymorphism in the Saudi population, DNA samples were analysed using restriction endonucleases, Mst II and Hpa I. Both beta A and beta S genes showed extensive polymorphism and were found to be linked to 13.0 kb, 7.6 kb, 7.0 kb, and 5.6 kb Hpa I fragments. Three DNA samples out of a total of 436 analysed, had beta-globin gene linked to three Hpa I fragments of the sizes 13.0 kb, 7.6 kb, and 5.6 kb. In this paper we present our findings and discuss the possibility of multiple beta-globin loci.
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