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  • Title: Effects of adrenoceptor agonists and antagonists on the firing of neurons in the rat A1 noradrenergic region.
    Author: Kaba H, Saito H, Otsuka K, Seto K.
    Journal: Jpn J Physiol; 1986; 36(4):795-9. PubMed ID: 2878101.
    Abstract:
    Noradrenaline (NA), but not clonidine applied microiontophoretically, inhibited the firing of neurons in the rat A1 noradrenergic region, whereas intravenous clonidine dose-dependently inhibited their firing (ED50 = 18.3 micrograms/kg). The NA-induced inhibition was blocked by the beta-antagonist timolol, but not by the alpha-antagonists phentolamine or piperoxane. These results suggest that neurons in the A1 region possess beta-adrenoceptors rather than alpha-adrenoceptors near their cell bodies, and that systemically administered clonidine acts indirectly on these cells.
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