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  • Title: Iminyl-Radicals by Oxidation of α-Imino-oxy Acids: Photoredox-Neutral Alkene Carboimination for the Synthesis of Pyrrolines.
    Author: Jiang H, Studer A.
    Journal: Angew Chem Int Ed Engl; 2017 Sep 25; 56(40):12273-12276. PubMed ID: 28783243.
    Abstract:
    The visible-light-promoted decarboxylation of α-imino-oxy propionic acids for the generation of iminyl radicals has been accomplished through the use of Ir(dFCF3 ppy)2 (dtbbpy)PF6 as a photoredox catalyst. Different from visible-light-promoted homolysis and single-electron reduction of oxime derivatives, this strategy provides a novel catalytic cycle for alkene carboimination through a sequence comprising N-radical generation, iminyl radical cyclization, intermolecular conjugate addition to a Michael acceptor, and single-electron reduction to afford various pyrroline derivatives in an overall redox-neutral process. The indolizidine alkaloid skeleton could be easily constructed from a pyrroline derivative prepared by this synthetic method.
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