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  • Title: Eseroline depresses the responses of dorsal horn neurons to C-fiber afferents in the spinal rat.
    Author: Braga PC, Biella G, Fraschini F, Tiengo M.
    Journal: Neurosci Lett; 1986 Oct 30; 71(1):113-7. PubMed ID: 2878395.
    Abstract:
    Eseroline not only has some structural features in common with morphine but also has a specific antinociceptive action like opioid drugs. The effects of eseroline on the responses of rat dorsal horn lamina V neurons to C-fiber-related noxious stimuli were investigated. The data obtained showed that 15 min after eseroline administration, the neuronal responses to C-fiber-related afferents were almost totally suppressed. Morphine was used as reference drug. The postulated action of eseroline on opioid receptors was confirmed by reversal of eseroline-driven cell activity after naloxone injection.
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