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  • Title: [Changes in the health state of schizophrenic patients in neuroleptic therapy].
    Author: Heim M.
    Journal: Psychiatr Neurol Med Psychol (Leipz); 1986 Aug; 38(8):483-7. PubMed ID: 2878452.
    Abstract:
    The state of health of 135 schizophrenic patients was examined during therapy with a nigrostriatal (Haloperidol) and a mesolimbic (Clozapin) neuroplegic drug, and compared with the situation during treatment without neuroplegics. Among the methods used was the state of health scale of von Zerssen; the neuroleptic threshold was tested using Haase's handwriting test. There was evidence that the patient's health was primarily affected, but individual differential treatment with neuroplegics produced a significant improvement in this important respect. Contrary to Haase, we noticed nothing to convince us of a link between the antipsychotic efficacy of the neuroplegics under investigation and the neuroleptic threshold.
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