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  • Title: Effect of adrenalectomy on the pancreas of db/db mice.
    Author: Spear GS, Ohshima K, Bray GA, Caple MV.
    Journal: Horm Metab Res; 1986 Nov; 18(11):743-5. PubMed ID: 2878865.
    Abstract:
    Adrenalectomy has been performed in the diabetic mouse and the islet immunohistochemistry studied. Adrenalectomy restored blood glucose to normal. Mean islet size of diabetic animals was larger than that of either adrenalectomized diabetic animals or of lean controls. Adrenalectomy restored the immunohistochemical appearance of the islets to normal when examined with anti-insulin, anti-glucagon and anti-somatostatin antisera.
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