These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A highly polymorphic locus on chromosome 16q revealed by a probe from a chromosome-specific cosmid library.
    Author: Bufton L, Mohandas TK, Magenis RE, Sheehy R, Bestwick RK, Litt M.
    Journal: Hum Genet; 1986 Dec; 74(4):425-31. PubMed ID: 2878870.
    Abstract:
    A cosmid library was constructed from genomic DNA of a human-mouse somatic cell hybrid containing an 11q-16q translocation chromosome as the only human DNA. Cosmids with human inserts were prehybridized with total human DNA and were screened to find probes that revealed highly polymorphic loci. From one such cosmid, CF33-79, a single-copy subclone was isolated which revealed an insertion/deletion polymorphism with at least 11 alleles and a PIC of 0.77. Using a somatic cell hybrid mapping panel, the subclone was mapped to chromosome 16. By in situ hybridization with the entire cosmid used as a probe, chromosomal localization was shown at 16q22----24.
    [Abstract] [Full Text] [Related] [New Search]