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  • Title: Metabolic changes in rat brain synaptosomes after exposure to sulfide in vivo.
    Author: Rafalowska U, Zitting A, Savolainen H.
    Journal: Toxicol Lett; 1986 Dec; 34(2-3):193-200. PubMed ID: 2879368.
    Abstract:
    The effects of exposure of rats to sulfide and the action of exogenous heme were studied in rat-brain synaptosomes. Exposure to sulfide impaired the respiration of synaptosomes which was reversed by heme (4 mg/kg body weight). Sodium sulfide caused partial inhibition of gamma-aminobutyric acid (GABA) and dopamine uptake, strongly inhibited veratridine-dependent release of these neurotransmitters and reduced veratridine-dependent changes in transmembrane electrical potential. Heme treatment did not reverse these changes.
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