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  • Title: Antral gastrin-producing G-cells and somatostatin-producing D-cells in peptic ulcer.
    Author: Torres AJ, Ortega L, Blanco J, Fernandez-Durango R, Hernandez F, Suarez A, Cuberes R, Sanz J, Balibrea JL.
    Journal: Virchows Arch A Pathol Anat Histopathol; 1986; 410(3):165-71. PubMed ID: 2879377.
    Abstract:
    The number of G cells and D cells per area unit and the G cell/D cell ratio was studied in control subjects and patients with duodenal or gastric ulcer. A great inter-individual variation in the population density of both types of cells was observed in the three groups studied. G cell density was significantly decreased in both duodenal and gastric ulcer patients, when compared with controls; whereas no difference in G cell density was seen between duodenal ulcer patients and gastric ulcer patients. However, D cell density was significantly decreased in duodenal ulcer patients when compared with control subjects and gastric ulcer patients. In this latter group, D cell density was also lower than in control subjects. A significant positive linear correlation between G cell number and D cell number was found in the three groups studied. The G cell/D cell ratio was significantly increased in duodenal and gastric ulcer patients when compared with controls. This was mainly due to a decrease in D cell numbers. It is concluded that a local deficit in antral D cells in patients with peptic ulcer may favor the pathogenesis of ulcer disease.
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