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  • Title: Acute renal effects of beta-blockers.
    Author: Zech P, Pozet N, Labeeuw M, Laville M, Hadj-Aissa A, Arkouche W, Poncet JF.
    Journal: Am J Nephrol; 1986; 6 Suppl 2():15-9. PubMed ID: 2879466.
    Abstract:
    The effects on renal function of a single dose of six different beta-blockers (atenolol, propranolol, metoprolol, acebutolol, nadolol, and pindolol) have been evaluated in 51 hypertensive patients with normal glomerular filtration rate (GFR). Most drugs, except pindolol, induce a 10-20% decrease in GFR and renal plasma flow, although differences in the magnitude and the pattern of this fall are evident. The fractional excretion of sodium is generally depressed by 20-40%. These data suggest a limited renal tolerance of most beta-blockers during acute administration, irrespective of their pharmacological characteristics.
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