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  • Title: Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients.
    Author: Salvetti A, Leonetti G, Bernini GP, Rupoli L, Lucarini AR, Sangiorgio P, Mauro M, Di Stratis P, Zanchetti A.
    Journal: Am J Nephrol; 1986; 6 Suppl 2():45-9. PubMed ID: 2879473.
    Abstract:
    Tertatolol, a new nonselective beta-adrenoceptor blocker, was administered to 11 hypertensive patients in a short-term study. Systolic and diastolic blood pressure and heart rate were significantly decreased when compared to the placebo period: in spite of that glomerular filtration rate and renal plasma flow were unchanged. The administration of metoclopramide (a dopaminergic receptor antagonist) caused a significant reduction of renal plasma flow and a significant rise of renal vascular resistances during placebo, but no change during tertatolol therapy. A possible interference of tertatolol on dopaminergic receptors is discussed as the mechanism responsible for the unmodified renal plasma flow despite the significant blood pressure lowering with tertatolol.
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