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  • Title: Two Furanosesterterpenoids from the Sponge Luffariella variabilis.
    Author: Ahmadi P, Higashi M, Voogd NJ, Tanaka J.
    Journal: Mar Drugs; 2017 Aug 10; 15(8):. PubMed ID: 28796183.
    Abstract:
    Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC50 1.0 µM against NBT-T2 cells.
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