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  • Title: Congenital neurocristic cutaneous hamartoma with poliosis: A case report.
    Author: Wilson LM, Beasley KJ, Sorrells TC, Johnson VV.
    Journal: J Cutan Pathol; 2017 Nov; 44(11):974-977. PubMed ID: 28802002.
    Abstract:
    Neurocristic cutaneous hamartomas (NCH) are rare, pigmented skin lesions derived from the abnormal migration of neural crest cells. We report the case of a 57-year-old female with a congenital localized area of poliosis and underlying pigmented patch on her scalp. Analysis of 2 punch biopsies yielded features consistent with NCH. Histopathology revealed schwannian-differentiated spindle cells and melanocytic components in the dermis. The spindle cells stained positively for S-100 and the stroma showed a prominent CD34 staining. The melanocytes were positive for melanoma triple stain (HMB-45, Melan A, Tyrosinase) and S-100. As the presentation of NCH and focal poliosis has yet to be described, we will present a literature review of NCH and discuss common features and associations of poliosis.
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