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  • Title: Stimulation by a tumor-promoting phorbol ester of acetyl-CoA carboxylase activity in isolated rat hepatocytes.
    Author: Vaartjes WJ, de Haas CG, Geelen MJ, Bijleveld C.
    Journal: Biochem Biophys Res Commun; 1987 Jan 15; 142(1):135-40. PubMed ID: 2880584.
    Abstract:
    Acetyl-CoA carboxylase (EC 6.4.1.2) in hepatocytes from meal-fed rats was activated by phorbol myristate acetate (PMA) in a time- and concentration-dependent fashion. This activation can account for the PMA-induced stimulation of de novo fatty acid synthesis. Purified rat-liver acetyl-CoA carboxylase was found to be phosphorylated and activated by protein kinase C, thus providing a possible mechanism for the metabolic action of PMA in intact hepatocytes.
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