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  • Title: Quantitative diffusion-weighted magnetic resonance imaging assessment of chemotherapy treatment response of pediatric osteosarcoma and Ewing sarcoma malignant bone tumors.
    Author: Degnan AJ, Chung CY, Shah AJ.
    Journal: Clin Imaging; 2018; 47():9-13. PubMed ID: 28806574.
    Abstract:
    OBJECTIVE: Assessment of tumor response to chemotherapy is essential in managing malignant pediatric bone tumors prior to resection. SUBJECTS AND METHODS: Pre-chemotherapy and post-chemotherapy osteosarcoma and Ewing sarcoma cases (n=18) were analyzed with apparent diffusion coefficient (ADC) values measured by two readers. RESULTS: Treated tumors demonstrated significantly greater ADC values compared to untreated tumors (p<0.001). Intraclass correlation coefficients ranged between 0.858 and 0.935. No significant tumor volume differences were observed. Regression analysis demonstrated average ADC as the best predictor of treatment. CONCLUSIONS: Our study suggests that ADC values may be useful for evaluating chemotherapeutic response of malignant pediatric bone tumors.
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