These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Regional localization and characterization of a DNA segment on the long arm of chromosome 21.
    Author: Cooper DN, Niemann SC, Gosden JR, Mitchell AR, Goate AM, Rajendran GS, Miller DA, Lim L, Schmidtke J.
    Journal: Hum Genet; 1987 Feb; 75(2):129-35. PubMed ID: 2880794.
    Abstract:
    A human genomic DNA fragment, pAM37 (HGM8; D21S22), was mapped to chromosome 21q2.1-q2.21 by in situ hybridization. This segment is therefore situated on the boundary of the "pathological region" of Down syndrome. A genomic restriction map encompassing 35 kb of chromosome 21 was derived and two restriction fragment length polymorphisms (RFLPs) were mapped and characterized. A homologous sequence was detected in the mouse genome but no homologous RNA was detected in a range of human tissues. This DNA segment will contribute to the linkage mapping of chromosome 21 and will facilitate delineation of the pathological region of Down syndrome.
    [Abstract] [Full Text] [Related] [New Search]