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  • Title: N-formylpenicillamine and penicillamine as degradation products of penicillins in solution.
    Author: Bird AE, Jennings KR, Marshall AC.
    Journal: J Pharm Pharmacol; 1986 Dec; 38(12):913-6. PubMed ID: 2880966.
    Abstract:
    The degradation of several penicillins in unbuffered aqueous solution produces N-formylpenicillamine, in some cases in high yield. Very little or no penicillamine is formed under these conditions. N-Formylpenicillamine was produced from benzylpenicillin at pH values between 2.5 and 7, with a maximum yield of 30% at pH 5, whereas penicillamine was produced only at pH 5 or below in a yield of less than 1%. Benzylpenicillenic acid at pH 5 gave a 20% yield of N-formylpenicillamine and no penicillamine whereas benzylpenicilloic, penilloic and penillic acids gave no N-formylpenicillamine and a small amount of penicillamine.
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