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  • Title: The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice.
    Author: Schrier DJ, Moniot S, Gluckman MI, Gilbertsen RB.
    Journal: J Pharm Pharmacol; 1987 Jan; 39(1):57-9. PubMed ID: 2880988.
    Abstract:
    A topical preparation of meclofenamic acid (Meclomen) was tested for anti-inflammatory activity in a murine model of carrageenan footpad oedema. The preparation significantly inhibited swelling when applied to the carrageenan-injected paw. Maximum inhibition was observed 4-5 h after carrageenan injection. The topical effects could not be attributed to systemic absorption because the preparation was more inhibitory when applied topically to the carrageenan-injected paw than to a distant site or orally.
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