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  • Title: Mechanism of action of L-leucyl-glycinamide and its effect on Parkinson's disease.
    Author: Xu DL, Yu WC, Pan GB, Chen SD.
    Journal: Adv Neurol; 1987; 45():587-90. PubMed ID: 2881450.
    Abstract:
    PLG potentiates the action of levodopa in 6-OH-DA-treated rats. PLG plus levodopa is more effective than levodopa alone. PLG-treated rats have a decreased concentration of Leu-enkephalin in the caudate nucleus as compared with the control. Preliminary results of using PLG (400 mg/day) for 10 days for treating PD are satisfactory. The mode of action of PLG with relation to dopamine-enkephalin interaction is discussed.
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