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Title: Inhibition of trout (Salmo gairdneri R.) PBG-synthase by some metal ions (Mg2+, Pb2+, Zn2+). Author: González O, Fernández J, Martín M. Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1987; 86(1):163-7. PubMed ID: 2881712. Abstract: The effect of metal ions on the activity of trout kidney and liver PBG-synthase was investigated. Heavy metals inhibited the kidney enzyme in a complex manner. Kinetic analysis of the inhibition of liver activity by Pb2+ (Ki = 1.3 mM) was consistent with non-competitive inhibition, whereas Zn2+ (Ki = 1.3 mM) and Mg2+ (Ki = 3.5 mM) were competitive inhibitors.[Abstract] [Full Text] [Related] [New Search]