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  • Title: The effect of levobunolol on aqueous humor dynamics.
    Author: Yablonski ME, Novack GD, Burke PJ, Cook DJ, Harmon G.
    Journal: Exp Eye Res; 1987 Jan; 44(1):49-54. PubMed ID: 2881799.
    Abstract:
    We evaluated the acute effects of installation of 0.5% levobunolol on aqueous humor dynamics in a double-masked study in 18 patients with ocular hypertension. Aqueous flow was measured by fluorophotometry and total outflow facility by tonography. Aqueous flow decreased approximately 29% in the eyes treated with levobunolol. Total outflow facility and episcleral venous pressure measurements were similar in levobunolol-treated eyes and contralateral eyes treated with vehicle. A 36% decrease in intraocular pressure was observed in the levobunolol-treated eyes and a slight intraocular pressure reduction was seen in the vehicle-treated eyes. The results of this study indicate that, similar to timolol, levobunolol lowers intraocular pressure primarily by decreasing aqueous humour production.
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