These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: Evaluation of 'CKD-EPI Pakistan' Equation for estimated Glomerular Filtration Rate (eGFR): AComparison of eGFR Prediction Equations in Pakistani Population.
    Author: Ahmed S, Jafri L, Khan AH.
    Journal: J Coll Physicians Surg Pak; 2017 Jul; 27(7):414-418. PubMed ID: 28818163.
    Abstract:
    OBJECTIVE: To evaluate the results of 24-hour urinary creatinine clearance (CrCl) with estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI Pakistan (CKD-EPI Pak), Cockcroft Gault (CG) and 4-variable Modification of Diet in Renal Disease (MDRD) equations. STUDY DESIGN: Descriptive, cross-sectional study. PLACE AND DURATION OF STUDY: Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, from June to October 2013. METHODOLOGY: Laboratory data of subjects ≥18 years ordering 24-hour urinary CrCl from June to October 2013 was retrieved. Statistical comparison of eGFR using CKD-EPI, CKD-EPI Pak, CG and MDRD with the timed urine collection CrCl was done using regression analysis. RESULTS: The mean age of the group (n=670) was 51.3 ±15.4 years with a median of 53 (IQR:22.3) years, 55.7% being males. Median BMI of males and females was 26.98 kg/m2(IQR: 7.09) and 26.16 kg/m2(IQR: 6.97), respectively. Mean GFR using 24-hour creatinine clearance was 57.1 ±35.9 ml/min/1.73m2 with a median of 51 ml/min/1.73m2. Urinary creatinine clearance showed strong correlation with CG, MDRD, CKD-EPI and CKD-EPI Pak, showing r=0.78, r=0.79, r=0.82, and r=0.82, respectively. Sensitivity was highest for the CKD-EPI Pakistan (84.7%). Similarly, CKD-EPI Pakistan equation showed the highest agreement (88.7%) with CrCl compared to the other formulae. CONCLUSION: The CKD-EPI Pak equation is more accurate and precise than the CG, CKD-EPI and MDRD in estimating GFR in Pakistani population.
    [Abstract] [Full Text] [Related] [New Search]