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  • Title: Three-point linkage analysis employing C3 and 19cen markers assigns the myotonic dystrophy gene to 19q.
    Author: Friedrich U, Brunner H, Smeets D, Lambermon E, Ropers HH.
    Journal: Hum Genet; 1987 Mar; 75(3):291-3. PubMed ID: 2881880.
    Abstract:
    In seven large families with myotonic dystrophy (DM) comprising 102 individuals, linkage studies were performed employing restriction fragment length polymorphisms in the complement component 3 gene and the 19cen C banding heteromorphism as genetic markers. Three-point linkage analysis excludes DM from the 19cen-C3 segment and strongly supports its assignment to the proximal long arm of chromosome 19.
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