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  • Title: Effect of lapachol, a naphthaquinone isolated from Tectona grandis, on experimental peptic ulcer and gastric secretion.
    Author: Goel RK, Pathak NK, Biswas M, Pandey VB, Sanyal AK.
    Journal: J Pharm Pharmacol; 1987 Feb; 39(2):138-40. PubMed ID: 2882001.
    Abstract:
    Lapachol, a naphthaquinone isolated from the roots of Tectona grandis given at a dose of 5 mg kg-1 p.o. twice daily for 3 days was found to have an anti-ulcerogenic effect on subsequently induced experimental gastric and duodenal ulcers in rats and guinea-pigs. Its action appears to be associated with an effect on the protein content of gastric juice, and it reversed aspirin-induced changes in peptic activity, protein and sialic acid.
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