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  • Title: Altered language network in benign childhood epilepsy patients with spikes from non-dominant side: A resting-state fMRI study.
    Author: Fang J, Chen S, Luo C, Gong Q, An D, Zhou D.
    Journal: Epilepsy Res; 2017 Oct; 136():109-114. PubMed ID: 28822871.
    Abstract:
    Benign childhood epilepsy with centrotemporal spikes (BECTS) is one of the most common childhood epilepsy syndromes, and language deficits associated with BECTS have become a hot topic. This study investigated alterations of the language network in BECTS children with spikes from the non-dominant side in comparison with healthy controls. Twenty-three children with BECTS and 20 age-matched healthy controls were enrolled. Region of interest -based whole brain functional connectivity analysis was used to identify the potential differences in the functional connectivity of the Broca's area between the two groups. Increased positive functional connectivity within the Broca's region was detected mainly at the left superior frontal gyrus (Brodmann area 8), bilateral insula, and anterior and posterior cingulate in the BECTS group. No regions showed significantly decreased connection in the BECTS patients compared to the controls. This study suggested alterations in the language network that was related with the Broca's area in children with BECTS from the non-dominant side. Further studies with longitudinal assessments from the perceptive of functional neuroimaging are needed to illustrate the dynamic course of language development and corresponding neuroimaging evidence.
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