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  • Title: Effect of circulating somatostatin on exocrine pancreatic secretion in conscious dogs.
    Author: Köhler E, Beglinger C, Ribes G, Grötzinger U, Loubatiéres-Mariani MM, Gyr K.
    Journal: Pancreas; 1986; 1(5):455-9. PubMed ID: 2882502.
    Abstract:
    We determined the effects of exogenous somatostatin-14 (100 and 200 ng/kg/h; mimicking postprandial somatostatin concentrations) on pancreatic responses to a background infusion of secretion in combination with graded doses of CCK-8 in conscious dogs with chronic gastric and duodenal fistulas. The lower dose of somatostatin-14 (S-14), which produced S-14 plasma levels lower than measured after a meal, did not change basal or stimulated pancreatic secretion. The upper dose of S-14, which produced plasma S-14 concentrations slightly above the postprandial range, caused inhibition of pancreatic fluid and protein secretion to low doses of CCK-8 (p less than 0.05). The inhibition was surmountable with higher doses of CCK-8. We interpret these data as indicating that circulating S-14 is not an important hormonal regulator of exocrine pancreatic secretion.
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