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  • Title: Bioactive furanocoumarins from the stems and leaves of Clausena hainanensis.
    Author: Ma YL, Zhang C, Zhao WH, Shi S, He DN, Zhang P, Liu XH, Han TT, Fu YH, Liu YP.
    Journal: Nat Prod Res; 2018 Sep; 32(18):2159-2164. PubMed ID: 28826247.
    Abstract:
    A new furanocoumarin, clauhainanin A (1), together with seven known furanocoumarins (2-8), were isolated from the stems and leaves of Clausena hainanensis. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All known compounds (2-8) were isolated from C. hainanensis for the first time. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-8 exhibited significant inhibitory effects with IC50 values ranging from 1.36 to 18.96 μM.
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