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  • Title: Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques.
    Author: Yan JW, Zhu JY, Zhou KX, Wang JS, Tan HY, Xu ZY, Chen SB, Lu YT, Cui MC, Zhang L.
    Journal: Chem Commun (Camb); 2017 Aug 31; 53(71):9910-9913. PubMed ID: 28828456.
    Abstract:
    Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of the classical cationic cyanine scaffold IR-780 for in vivo imaging of amyloid-β plaques. In vivo NIRF imaging revealed that the probe could penetrate the blood-brain barrier and efficiently differentiate the living transgenic and wild-type mice.
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